| 163例严重药物性肝损害不良反应报告分析 |
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| 引用本文： | 王晓瑜,程能能.163例严重药物性肝损害不良反应报告分析[J].上海医药,2014(5):35-38. |
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| 作者姓名： | 王晓瑜 程能能 |
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| 作者单位： | [1]复旦大学药学院药理学教研室 上海 201203 [2]上海市药品不良反应监测中心上海200010 |
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| 摘 要： | 目的：探讨各类药物导致药物性肝损害的规律和特点。方法：对2011-2013年上海市药品不良反应监测数据库内163例严重药物性肝损害报告进行分析。结果：药物性肝损害涉及的怀疑药品品种繁多，抗感染药物、抗肿瘤药、心血管药物较易引起药物性肝损害。65岁及以上年龄段发生不良反应的比例明显高于其他年龄段；合并用药将增加药物性肝损害的发生率。结论：应重视药品不良反应监测，合理用药，预防药物性肝损害发生。
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| 关 键 词： | 药物性肝损伤 药物不良反应 合理用药 |
Retrospect analysis of 163 severe cases of drug-induced liver injury |
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| WANG Xiaoyu,CHENG Nengneng.Retrospect analysis of 163 severe cases of drug-induced liver injury[J].Shanghai Medical & Pharmaceutical Journal,2014(5):35-38. |
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| Authors: | WANG Xiaoyu CHENG Nengneng |
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| Institution: | 1. Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, China; 2. Shanghai Adverse Drug Reaction Monitoring Center, Shanghai 200233, China) |
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| Abstract: | Objective：To investigate the rule and characteristics of drug-induced liver injury （DILI）. Methods：One hundred and sixty-three cases of DILI in Adverse Drug Reaction Monitoring database of Shanghai during 2011-2013 were analyzed. Results：DILI can be caused by many kinds of drugs such as anti-infective, anti-neoplastic and cardiovascular drugs. The incidence of adverse drug reactions in the people aged 65 and over is much higher than that of other age groups. Drug combination will increase the incidence of DILI. Conclusion：Great attention should be paid to the monitoring of adverse drug reaction and the rational drug use so as to prevent the occurrence of DILI. |
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| Keywords: | drug-induced liver injury adverse drug reactions rational drug use |
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