不同年龄子宫颈癌临床特点分析

目的探讨不同年龄子宫颈癌的临床特点。方法对2003年1月至2008年12月间中山大学附属第三医院收治的116例子宫颈癌病例进行回顾性分析,其中≤35岁组13例,〉35岁组103例,比较两组的临床特点。结果≤35岁组0-Ia期、Ib-IIa期、IIb-III期、IV期所占比例分别是46.2%、30.7%、23.1%、0.0%,〉35岁组0-Ia期、Ib-IIa期、IIb-III期、IV期所占比例分别是11.6%、33.9%、40.8%、14.7%,两组比较差异有统计学意义（P〈0.05）;≤35岁组鳞癌、腺癌、腺鳞癌的比例分别是61.5%、30.8%、7.7%,〉35岁组鳞癌,腺癌,腺鳞癌的比例分别是91.3%、5.8%、2.9%,两组比较差异有统计学意义（P〈0.05）;≤35岁组淋巴转移率（38.5%）高于〉35岁组（12.6%）（P〈0.05）;≤35岁组与〉35岁组两组在组织学分级、宫颈肌层浸润、宫旁浸润方面比较,差异均无统计学意义（P〉0.05）。≤35岁组的平均生存时间为（45.7±2.5）月,〉35岁组的平均生存时间为（39.1±2.2）月,两组的生存曲线比较差异无统计学意义（P〉0.05）。结论年轻宫颈癌患者的临床分期以早期癌为主,腺癌、腺鳞癌的比例高,更易发生盆腔淋巴结转移,预后与〉35岁者相似。

Analysis of the clinical characteristics of cervical cancer patients with different age

Objective To study the clinical characteristics of cervical cancer patients with different ages.Methods The clinical characteristics of 116 cervical cancer cases,≤ 35-year-old group of 13 cases and 35-year-old group of 103 cases,were retrospectively analyzed,which were admitted from January 2003 to December 2008 in our hospital.Results There were statistically difference in clinical stage between the proportion of 0-Ia （46.2%）、Ib-IIa （30.7%）、IIb-III（23.1%）、IV （0.0%） in 35 years group and the proportion of 0-Ia（11.6%）、Ib-IIa（33.9%）、IIb-III （40.8%）、IV（14.7%） in 35 years group（P0.05）.The proportion of the squamous cell carcinoma、adenocarcinoma and adenosquamous carcinoma of pathological was 61.5%、30.8%、7.7% in 35 years group,which was statistically different to the proportion of 91.3%、5.8%、2.9% in 35 years group（P0.05）.The rate of lymph metastasis in 35 years group （38.5%）was higher than that of 12.6% in 35 years group（P0.05）.There was no statistically difference in histology differentiated grade,later-cervical infiltration and the level of infiltration cervical muscular between the two groups （P0.05）.No difference of survival curves was observed between two groups,the average survival time was（45.7±2.5）months in 35 years group and（39.1±2.2）months in 35 years group （P0.05）.Conclusion early clinical stage mainly in young cerrical cancer patients,higher rate of lymph metastasis and high proportion of adenocarcinoma and adenosquamous carcinoma,but having similar average survival time with the aged patients.