P53和MDM2基因表达及与膀胱癌生物学行为的关系

目的：研究P53基因和MDM2基因表达及与膀胱癌生物学行为的关系。方法：采用免疫组织化学方法检测49例膀胱移行细胞癌中P53基因和MDM2基因的表达。结果：P53基因的阳性表达率为51．0％（25／49），其表达率随膀胱癌的分期、分级升高而升高。MDM2基因的阳性表达率为32．7％（14／49），其表达率随膀胱癌的分期、分级降低而升高。单有P53基因阳性表达的膀胱癌几乎均为浸润性和中、低分化癌；而当P53基因并MDM2基因表达时，膀胱癌的侵袭性和恶性度明显降低。2年复发组和未复发组的P53基因和MDM2基因的阳性表达率差异均无显著性意义。结论：联合检测P53和MDM2基因表达可更准确地解释和描述膀胱癌的生物学行为。这两种基因表达与膀胱癌预关系值得进一步研究。

The expression and function of P53 gene and MDM2 gene in bladder cancer

Purpose:To investigate the expressions and functions of P53 gene and MDM2 gene in bladder cancer.Methods:The expressions of P53 gene and MDM2 gene in specimens of 49 cases of patients with bladder transitional cell carcinomas were studied by immunohitochemical method.Results:The positive expression rate of P53 gene was 51.0 %(25/49) and it increased with the tumor stage and grade increasing. The positive expression rate of MDM2 gene was 32.7 %(16/49) and it increased with the tumor stage and grade decreasing. The bladder tumors only having positive expression of P53 gene were most likely being invasive or middle and low differentiation tumors. While with both the P53 gene and the MDM2 gene positively expressed, the invasiveness and malignant degree of bladder cancers decreased significantly. The positive expression rate of either P53 or MDM2 gene in recurrence or non recurrence groups within two years have no significant difference.Conclusions:By detecting both genes expressions, the biological behavior of bladder cancer can be more accurately interpreted and described.