厄贝沙坦联合胺碘酮对阵发性房颤复律后维持窦性心律的效果

目的：观察厄贝沙坦联合胺碘酮对阵发性心房颤动复律后维持窦性心律的临床效果及其对左心房内径的影响。方法：选择阵发性心房颤动患者89例,分为胺碘酮治疗组（44例,单纯服用胺碘酮）,联合治疗组（45例,服用胺碘酮及厄贝沙坦）,随访12个月,观察两组患者治疗前后窦性心律维持率,左房内径的变化,并进行比较分析。结果：治疗12个月后,与胺碘酮组比较,联合治疗组窦性心律维持率明显提高（64.3%比81.4%）,左房内径明显减小[（40.12±10.6）mm比（34.10±10.11）mm],P均〈0.05。结论：厄贝沙坦联合胺碘酮对阵发性心房颤动复律后维持窦性心律的作用明显优于单用胺碘酮,且明显抑制左房扩大,无明显不良反应。

Maintenance of sinus rhythm by irbesartan combined with amiodarone after cardioversion in patients with paroxysmal atrial fibrillation

Objective:To study maintenance of sinus rhythm by irbesartan combined with amiodarone after cardioversion in patients with paroxysmal atrial fibrillation(PAF) and its influence on left atrial diameter.Methods:A total of 89 PAF patients were divided into amiodarone treatment group(n=44,only received amiodarone) and combination therapy group(n=45,received amiodarone and irbesartan).All patients were followed up for 12 months.Changes of maintenance rate of sinus rhythm and left atrial diameter before and after treatment were observed and compared between the two groups.Results:Compared with amiodarone group after 12 months,there was significant increase in maintenance rate of sinus rhythm(64.3% vs.81.4%) and significant decrease in left atrial diameter [(40.12±10.6) mm vs.(34.10±10.11) mm] in combination therapy group,P<0.05 both.Conclusion:Maintenance of sinus rhythm by irbesartan combined with amiodarone after cardioversion in patients with paroxysmal atrial fibrillation is significantly better than that of single amiodarone treatment,and irbesartan combined with amiodarone significantly inhibits left atrial enlargement without significant adverse reactions.