| 髓源性抑制细胞——肿瘤免疫治疗的新靶点 |
| |
| 引用本文： | 武丽华,王东亮. 髓源性抑制细胞——肿瘤免疫治疗的新靶点[J]. 实用肿瘤学杂志, 2012, 26(4): 369-372 |
| |
| 作者姓名： | 武丽华 王东亮 |
| |
| 作者单位： | 哈尔滨医科大学附属第三医院内八科,哈尔滨,150081 |
| |
| 摘 要： | 髓源性抑制细胞(Myeloid-derived suppressor cells,MDSCs)是在病理情况下扩增的一种髓源性抑制细胞群,其特点是能负向调节机体的抗肿瘤免疫反应从而促进肿瘤的发生和发展.通过阻断MDSCs的免疫抑制通路来提高肿瘤免疫治疗的效果,是一个颇有前景的治疗策略.
|
| 关 键 词： | 髓源性抑制细胞 免疫抑制 肿瘤免疫治疗 |
Myeloid-derived suppressor cells:a new target of cancer immunotherapy |
| |
| WU Lihua , WANG Dongliang. Myeloid-derived suppressor cells:a new target of cancer immunotherapy[J]. Journal of Practical Oncology, 2012, 26(4): 369-372 |
| |
| Authors: | WU Lihua WANG Dongliang |
| |
| Affiliation: | WU Lihua , WANG Dongliang ,ZHANG Yanqiao 1. Department of Internal Medicine,The Third Affiliated Hospital of Harbin Medical University, Harbin 150081 ; 2. The cancer Institute of Harbin Medical University,Harbin 150081 |
| |
| Abstract: | Myeloid - derived suppressor cells （MDSCs） are a heterogeneous population of myeloid derived cells Which were amplified in pathological status,which is characterized as negatively regulating the anti -tumor immune response with the result of promoting tumorigenesis and cancer development. It is a promising strategy to enhance the effect of cancer immunotherapy through blocking the immunosuppressive pathway of MDSCs. |
| |
| Keywords: | Myeloid - derived suppressor cells lmmunosuppression Tumor immunotherapy |
| 本文献已被 维普 万方数据 等数据库收录！ |
|
