老年食管癌患者放疗疗效及相关临床因素分析

目的 探讨老年食管癌患者放射治疗的近远期疗效及其影响因素。方法 回顾性分析哈尔滨医科大学附属第三医院70例自2001年1月—2007年12月间以放疗为主要治疗手段,年龄≥70岁的老年食管癌患者的近期疗效,1、2、3年生存率及其相关临床因素和毒副反应的耐受情况。结果 放疗后总有效率为88.5%。1、2、3年总生存率及无病生存率分别是62.28%和10.80%、27.51%和7.20%、13.89%和3.40%。单因素及多因素分析显示,影响生存期的主要因素为病变的长度、治疗前转移情况(P＜0.05)。急性放射性肺反应、急性放射性食管反应及骨髓抑制发生率分别为24.3%、64.3%和48.6%。结论 放射治疗老年食管癌患者近期疗效显著,耐受性好;影响其生存期的主要因素是治疗前病灶长度及是否有转移。

Clinical factors and their curative effect analysis in elderly esophageal cancer patients with radiotherapy

Objective To analyze the outcome and influencing factors of radiotherapy in elderly esophageal cancer patients. Methods Seventy patients over 70 years with esophageal cancer were treated mainly by radiotherapy from January 2001 to December 2007. recent effect, the 1,2,3 year survival rate and it＇s influencing factors, toxic side effects were analyzed retrospectively. Results After radiotherapy for 70 patients with esophageal cancer,the total effect rate was 88.5% （62/70）. The 1,2,3 year survival rate and disease free survival is 62.28% and 10.80% ,27.51% and 7.20% ,13.89% and 3.40% ,respectively. Using univariate and multivariate analysis, focal length and whether there is metastasis were significantly associated with the survival rate. Conclusion Radiotherapy for elderly patients with esophageal cancer had significant effect and well tolerated;focal length and whether there is metastasis were the main survival - related prognostic factors.