Review article: Leukocyte-endothelial dysregulation in systemic small vessel vasculitis |
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| Authors: | TANYA PANKHURST CAROLINE OS SAVAGE MARK A LITTLE |
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| Affiliation: | Renal Institute of Birmingham, School of Infection, Immunity and Inflammation, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK |
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| Abstract: | Aberrant interaction between the leukocyte and the endothelial cell (EC) results in the uncontrolled inflammation seen in systemic small vessel vasculitis. This review discusses our current understanding of this process and includes consideration of the role of adhesion molecules, proteases and the neutrophil respiratory burst. The effects of anti-neutrophil cytoplasm antibodies and anti-endothelial cell antibodies and their pathogenic roles are examined, and we look at experimental disease models. Specificity of disease-targetted endothelial beds and the role of circulating EC are discussed. |
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| Keywords: | leukocyte endothelium vasculitis inflammation anti-neutrophil-cytoplasm-antibody neutrophil |
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