Differential effects of phencyclidine upon hippocampal complex-spike and theta neurons |
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| Authors: | G Rose K Pang M Palmer R Freedman |
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| Affiliation: | 1. Department of Pharmacology, University of Colorado Health Sciences Center Denver, CO 80262 U.S.A.;2. Department of Psychiatry, University of Colorado Health Sciences Center Denver, CO 80262 U.S.A.;3. Department of Veterans Administration Medical Research Service, Denver, CO 80262 U.S.A. |
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| Abstract: | The effects of local application of phencyclidine (PCP) upon hippocampal CA1 neurons were investigated in urethane-anesthetized rats. Hippocampal neurons were classified on the basis of extracellularly recorded action potential duration as either complex-spike or theta cells prior to PCP administration. PCP depressed spontaneous firing of 46 of 48 complex-spike cells, but excited 12 of 13 theta neurons. This result demonstrates that hippocampal complex-spike and theta neurons may be differentiated of theta neurons were greatly attenuated or absent in rats pretreated with DSP4, a neurotoxin which selectively destroys noradrenergic pathways. This latter finding lends additional support to the hypothesis that the effects of locally applied PCP are mediated via noradrenergic mechanisms. |
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| Keywords: | hippocampus phencyclidine complex-spike cell theta neuron DSP4 |
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