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| 表达Tie2基因的单核细胞研究进展 | |
| 引用本文： | 舒伟,许淑茹,袁志刚. 表达Tie2基因的单核细胞研究进展[J]. 国际免疫学杂志, 2010, 33(1): 5-8. DOI: 10.3760/cma.j.issn.1673-4394.2010.01.002 |
| 作者姓名： | 舒伟 许淑茹 袁志刚 |
| 作者单位： | 广西医科大学基础医学院细胞生物学与遗传学教研室,南宁,530021 |
| 摘 要： | 肿瘤血管的生成和发展在肿瘤的生长和恶化过程中起着关键作用。一类表达Tie2基因的单核细胞（TEM）通过一些生长因子和化学信号被募集到肿瘤组织中，旁分泌细胞因子促进肿瘤血管的生成和发展。TEM在促进肿瘤血管形成中起着重要作用，与血管内皮细胞祖细胞（EPC）不同的是，TEM只是在肿瘤的血管生成中起促进作用，但在肿瘤周围临近的正常组织中没有发现其存在，TEM被认为是一类肿瘤组织特异性的细胞。以TEM为载体细胞，通过TEM表达抗肿瘤药物，靶向递送的抗肿瘤药物能够有效的抑制肿瘤的生长和恶化。 |
| 关 键 词： | Tie2 TEM 肿瘤靶向治疗 |
Research progress of Tie2-expressing monocytes |
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| SHU Wei,XU Shu-ru,YUAN Zhi-gang. Research progress of Tie2-expressing monocytes[J]. International Journal of Immunology, 2010, 33(1): 5-8. DOI: 10.3760/cma.j.issn.1673-4394.2010.01.002 | |
| Authors: | SHU Wei XU Shu-ru YUAN Zhi-gang |
| Affiliation: | . (School of Preclinical Science, Guangxi Medical University, Nanning 530021, China) |
| Abstract: | Neovascularization is significant for tumor growth and progression to malignancy. Tie2 expressing monocytes (TEM) are recruited into tumors by several growth factors and chemokines, and promote tumor angiogenesis in a manner of paracrine. Moreover, TEM, while stimulating tumor angiogenesis, do not actively incorporate into blood vessels as endothelial progenitor cells ( EPC) , but are incorporated in all new-forming blood vessel. TEM were found only in tumors and were missing in nonneoplastic tissues adjacent to tumors. Novel anticancer therapies that selectively target tumors by these cells have showed significant antitumor responses and near complete abrogation of metastasis. |
| Keywords: | Tie2 TEM |
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