2型糖尿病患者血浆致动脉硬化指数与其他几种动脉硬化指数的应用价值比较

目的比较2型糖尿病（DM）血浆致动脉硬化指数（AIP）、低密度脂蛋白胆固醇（LDL-C）／高密度脂蛋白胆固醇（HDL—C）比值及动脉硬化指数（AI）和血脂综合指数（LCI）的应用价值。方法测定124例2型DM患者和111名正常对照者三酰甘油（TG）、总胆固醇（TC）、HDL—C等,计算LDL-C、AIP、LDL—C／HDL—C比值、AI和LCI。将2型DM患者分为HDL—C〈0．91mmol／L及HDL—C≥0．91mmol／L2组进行分析。结果2型DM组的AIP、AI和LCI均高于正常对照组（P〈0．001）,其中AIP值最高,A1次之。2型DM患者HDL-C〈0．91mmol／L组的AIP、AI、LDL—C／HDL—C比值均高于HDL-C≥0．91mmol／L组（P〈0．001）,AIP的升高较明显。2型DM血脂升高组调脂前后AIP差异明显（P〈0．001）。结论比较AIP和其他3种指数,以AIP差异最明显。AIP是反映2型DM患者发生动脉粥样硬化危险性最有判断价值的指标。

Comparison on the application value of the atherogenic index of plasma with other arteriosclerosis indexes in type 2 diabetes mellitus patients

Objective To compare the application value of the atherogenic index of plasma （AIP）, low-density lipoprotein cholesterol （LDL-C） / high-density lipoprotein cholesterol （HDL-C）, arterial stiffness index （AI） and lipoprotein combine index （LCI） in patients with type 2 diabetes mellitus （ DM ）. Methods The levels of triglyceride （TG）, total cholesterol （TC） and HDL-C in 124 rype 2 DM patients and 111 healthy controls were determined and LDL- C, LDL-C/HDL-C, AlP, AI and LCI were calculated. Then the type 2 DM patients were classified into two groups： HDL-C 〈 0. 91 mmol/L group and HDL-C ≥0.91 mmol/L group. Results The AIP, AI and LCI in type 2 DM patients were higher than those in healthy controls （P 〈 0.001 ）. Among these indexes, AIP was the most sensite, and the next in order was AI. AI,LDL-C/HDL-C and especially AlP in HDL-C 〈0.91 mmol/L group were higher than that in HDL-C ≥0.91 mmol/L group（ P 〈 0.01 ）. The AlP in blood lipid rising group had significant difference between before and af- ter the treatment （P 〈 0. 001 ）. Conclusions Comparatively AIP is better than other arteriosclerosis indexes. AIP is the most valuable index for determining artherosclerosis and reflecting its risk in type 2 DM patients.