Defective Ultraviolet-Induced DNA Repair in Bone Marrow Cells and Peripheral Lymphocytes of Patients with Refractory Anemia with Excess of Blasts |
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Authors: | MURTHY P BALAKRISHNA; KAMADA NANAO; KURAMOTO ATSUSHI |
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Institution: | Department of Internal Medicine, Research Institute for Nuclear Medicine and Biology, Hiroshima University Hiroshima |
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Abstract: | The extent of ultraviolet (UV) irradiation-induced DNA repairwas measured in bone marrow cells and peripheral lymphocytesof patients with refractory anemia with excess of blasts (RAEB).Bone marrow cells from RAEB, when exposed to a 2 J/m dose ofUV, exhibited 50% lower incorporation of tritiated thymidinethan those of control subjects. A similar finding was observedin the peripheral lymphocytes. These data suggest that bonemarrow cells and peripheral lymphocytes from RAEB are deficientin repair of UV-induced lesions by DNA. Furthermore, this impairedDNA repair efficiency in RAEB was not related to the presenceor absence of a karyotype abnormality. |
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