| Nm23-H_1基因表达与食管癌淋巴结转移相关性的研究 |
| |
| 引用本文： | 张临友,魏关春,刘大仲,谭佩林. Nm23-H_1基因表达与食管癌淋巴结转移相关性的研究[J]. 中国急救医学, 2000, 0(1) |
| |
| 作者姓名： | 张临友 魏关春 刘大仲 谭佩林 |
| |
| 作者单位： | 哈尔滨医科大学第二临床医学院胸外科!150086(张临友,刘大仲,谭佩林),黑龙江省清河林业局职工医院(魏关春) |
| |
| 摘 要： | 目的 研究食管癌组织nm23-H1基因表达及其与淋巴结转移的关系。方法 应用免疫组化S-P法检测54例食管癌标本中nm23-H1基因的表达。结果 26例无淋巴结转移的食管癌中,有14例阳性表达,而在28例有淋巴结转移的食管癌中,13例阳性表达,两者无显著性差异。26例无淋巴结转移的食管癌中,nm23-H1基因的平均阳性表达率为396%,在28例有淋巴结转移的食管癌中,平均阳性表达率为172%,两者差异显著。结论 nm23-H1基因表达与否与食管癌的转移无关,但其表达水平的降低与食管癌的转移有关。
|
| 关 键 词： | nm23-H_1 食管癌 免疫组化S-P法 |
The relationship between nm23-H_1 gene expression and lymph node metastasis of the esophageal squamous cell carcinoma |
| |
| ZHANG Lin-you,WEI Guan-chun,LIU Da-zhong,et al.. The relationship between nm23-H_1 gene expression and lymph node metastasis of the esophageal squamous cell carcinoma[J]. Chinese Journal of Critical Care Medicine, 2000, 0(1) |
| |
| Authors: | ZHANG Lin-you WEI Guan-chun LIU Da-zhong et al. |
| |
| Affiliation: | ZHANG Lin-you,WEI Guan-chun,LIU Da-zhong,et al.The Second Affiliated Hospital,Harbin Medical University,Harbin Heilongjiang 150086,China [ |
| |
| Abstract: | Objective To understand the relationship between the expression of nm23-H 1 gene and lymph node metastasis in the tissue of esophageal squamous cell carcinoma(ESCC).Method The expression of nm23-H 1 protein was examined in 26 ESCC without lymph node metastasis and 28 with lymph node metastasis using immunohistochimical S-P method Results Fourteen of 26 ESCC without lymph node metastasis and 14 of 23 ESCC with lymph node metastasis were positive for nm23-H 1 staining while the nm23-H 1 protein average positive rates were 39.6% and in ESCC without lymph node metastasis and 17.2% in ESCC with lymph node metastasis respectively.Conclusion The expression was not correlated with lymph node metastasis,but reduced expression of nm23-H 1 gene was associated with lymph node metastasis. [ |
| |
| Keywords: | nm23-H 1 gene Esophageal squamous cell carcinoma Immunohistochimical S-P method |
| 本文献已被 CNKI 等数据库收录！ |
|
