复肾汤治疗小儿紫癜性肾病临床研究

目的:观察复肾汤对紫癜性肾病患儿尿红细胞、24 h尿蛋白定量和凝血功能的影响。方法:选取86例紫癜性肾病患儿,按随机数字表法分为对照组和试验组各43例。对照组给予去除诱因、抗过敏和抗感染等常规基础治疗,同时加用低分子量肝素钙皮下注射,试验组在对照组基础上加用复肾汤治疗。记录2组患者治疗前后的中医证候积分、临床疗效、尿红细胞、24 h尿蛋白、凝血功能指标。结果:试验组总有效率为97.56%,高于对照组76.74%(P<0.05)。治疗前,2组中医证候积分、尿红细胞、24 h尿蛋白定量比较,差异无统计学意义(P>0.05)。治疗后,2组中医证候积分、尿红细胞、24 h尿蛋白含量较治疗前降低(P<0.05),且试验组中医证候积分、尿红细胞、24 h尿蛋白定量低于对照组(P<0.05)。治疗前,2组凝血功能指标比较,差异均无统计学意义(P>0.05)。治疗后,2组活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)较治疗前升高(P<0.05),D-二聚体(DDI)、纤维蛋白原(FIB)较治疗前降低(P<0.05);试验组APTT、PT高于对照组(P<0.05),DDI、FIB低于对照组(P<0.05)。结论:复肾汤治疗紫癜性肾病患儿疗效显著,可明显改善尿红细胞、24 h尿蛋白含量及凝血功能指标,值得在临床上加以推广应用。

Clinical Study on Fushen Tang for Children with Purpura Nephropathy

Objective:To observe the effect of Fushen tang on urine erythrocyte,24 h urine protein and coagulation function in children with purpura nephropathy.Methods:A total of 86 cases of children with purpura nephropathy were divided into the control group and the experiment group according to the random number table,43 cases in each group.Both groups were given routine basic treatment including inducement removing,anti-allergy and anti-infection and subcutaneous injection with low molecular weight heparin calcium.The experiment group was additionally given Fushen tang.The indexes of Chinese medicine syndrome scores,clinical effect,urine erythrocyte,24-hour urine protein and coagulation function in the two groups were recorded before and after treatment.Results:The total effective rate was 97.56%in the experiment group,higher than that of 76.74%in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparison of Chinese medicine syndrome scores and the content of urine erythrocyte and 24-hour urine protein between the two groups(P>0.05).After treatment,Chinese medicine syndrome scores and the content of urine erythrocyte and 24-hour urine protein in the two groups were decreased when compared with those before treatment(P<0.05)and the above indexes in the experiment group were lower than those in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparison of the indexes of coagulation function between the two groups(P>0.05).After treatment,the activated partial thrombin time(APTT)and prothrombin time(PT)in the two groups were increased when compared with those before treatment(P<0.05),while d-dimer(DDI)and fibrinogen(FIB)were decreased when compared with those before treatment(P<0.05);APTT and PT in the experimental group were higher than those in the control group(P<0.05),while DDI and FIB were lower(P<0.05).Conclusion:The application of Fushen tang for children with purpura nephropathy has significant curative effect,which can obviously improve the content of urine erythrocyte and 24h urine protein and the indexes of coagulation function,and is worthy of clinical promotion and application.