Cellular immune responses and susceptibility to HIV-1 superinfection: a case-control study |
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| Authors: | Blish Catherine A Dogan Ozge C Jaoko Walter McClelland R Scott Mandaliya Kishorchandra Odem-Davis Katherine S Richardsonb Barbra A Overbaugh Julie |
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| Affiliation: | Division of Human Biology, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington, USA. cblish@stanford.edu |
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| Abstract: | ![]()
A case-control study was performed to determine the effects of HIV-1-specific cellular immune responses on the odds of acquiring a second HIV-1 infection (superinfection). Changes in the frequency of cytokine-producing or cytolytic CD8+ or CD4+ T cells were not associated with significant alterations in the odds of superinfection, suggesting that HIV-1 specific cellular immune responses at the level induced by chronic infection do not appear to significantly contribute to protection from HIV-1 superinfection. |
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