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痤疮发病机制中免疫应答的研究进展
引用本文:李佳妍. 痤疮发病机制中免疫应答的研究进展[J]. 医学综述, 2008, 14(8): 1124-1126
作者姓名:李佳妍
作者单位:广西南宁市红十字会医院皮肤科,南宁,530012
基金项目:广西南宁市科学研究与技术开发计划项目
摘    要:痤疮属于毛囊皮脂腺单位慢性炎性疾病。近来的研究表明,痤疮的发病机制中免疫应答与毛囊皮脂腺单位高表达白细胞介素1α、Toll样受体、可溶性白细胞介素2受体有关。痤疮瘢痕愈合的炎症皮损在消退期呈现高比例的皮肤归巢T细胞、巨噬细胞浸润、人类白细胞抗原高表达及毛细血管增生,提示迟发型超敏反应参与痤疮的炎症机制,免疫失衡在痤疮炎症发展中可能起关键性作用。

关 键 词:痤疮  细胞因子   Toll样受体  体液免疫  细胞免疫
文章编号:1006-2084(2008)08-1124-03
修稿时间:2007-09-03

Research Advances in Role of Immune Response in the Pathogenesis of Acne
LI Jia-yan. Research Advances in Role of Immune Response in the Pathogenesis of Acne[J]. Medical Recapitulate, 2008, 14(8): 1124-1126
Authors:LI Jia-yan
Affiliation:Department of Dematology;Guangxi Nanning Red Cross Hospital;Nanning 530012;China
Abstract:Acne is a chronic inflammatory disease of the pilosebaceous follicle.The significant expression of interleukin 1alpha-induced in the pilosebaceous unit,Toll-like receptors(TLRs),and soluble interleukin-2 receptors are considered to be involved in the pathogenesis of acne.A high percentage of skin homing T-cells,macrophages infiltration,strong expression of HLA-DR,and angiogenesis proliferation are symptoms in the retreat of the lesions with acne scars.It shows that delayed-type hypersensitivity is considere...
Keywords:Acne  Cytokine  Toll-like receptors  Humoral immunity  Cell immunity  
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