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| 灯盏花素片在健康人体内的药代动力学研究 | |
| 引用本文： | 姜岩,张伟,林秀艳,刘晶,信慧,陈迎,张卓伯. 灯盏花素片在健康人体内的药代动力学研究[J]. 中国实验方剂学杂志, 2011, 17(13): 110-112 |
| 作者姓名： | 姜岩 张伟 林秀艳 刘晶 信慧 陈迎 张卓伯 |
| 作者单位： | 1. 齐齐哈尔医学院附属第三医院,黑龙江齐齐哈尔,161000 2. 哈尔滨医科大学第四附属医院,黑龙江齐齐哈尔,150001 |
| 摘 要： | 目的:建立测定人血浆中灯盏花素浓度的高效液相色谱法。方法:色谱柱Kromasil C18(4.6 mm×250 mm,5μm);流动相甲醇-水-冰醋酸(30∶70∶1)检测波长:335 nm;灯盏乙素作为内标,用HPLC测定人血浆中灯盏花素浓度。结果:灯盏花素线性范围为0.30～18.0 mg·L-1,回归方程Y=0.008 7C-0.001 56(r=0.999 6);回收率>80%,日内和日间RSD均<10%。结论:方法简便、快速、准确,适用于灯盏花素药代动力学研究及血药浓度监测。 |
| 关 键 词： | 灯盏花素 高效液相色谱法 药代动力学 |
| 收稿时间： | 2011-03-17 |
Pharmacokinetics of Breviscapine Tablets in Healthy Volunteers |
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| JIANG Yan,ZHANG Wei,LIN Xiu-yan,LIU Jing,XIN Hui,CHEN Ying and ZHANG Zhuo-bo. Pharmacokinetics of Breviscapine Tablets in Healthy Volunteers[J]. China Journal of Experimental Traditional Medical Formulae, 2011, 17(13): 110-112 | |
| Authors: | JIANG Yan ZHANG Wei LIN Xiu-yan LIU Jing XIN Hui CHEN Ying ZHANG Zhuo-bo |
| Affiliation: | Third Affiliated Hospital of Qiqihar Medical College, Qiqihar 161000, China;Third Affiliated Hospital of Qiqihar Medical College, Qiqihar 161000, China;Third Affiliated Hospital of Qiqihar Medical College, Qiqihar 161000, China;Third Affiliated Hospital of Qiqihar Medical College, Qiqihar 161000, China;Third Affiliated Hospital of Qiqihar Medical College, Qiqihar 161000, China;Third Affiliated Hospital of Qiqihar Medical College, Qiqihar 161000, China;Fourth affiliated hospital of Qiqihar Medical College, Qiqihar 150001, China |
| Abstract: | |
| Keywords: | breviscapine HPLC pharmacokinetics |
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