秦皮甲素大鼠肠吸收动力学

目的:探讨秦皮甲素在大鼠各肠段的吸收动力学特征。方法:以大鼠在体肠灌流模型从吸收部位、药物浓度考察秦皮甲素的肠吸收动力学情况。结果:秦皮甲素在大鼠各肠段吸收有差异,十二指肠、空肠、回肠中的Ka依次为0.185 0,0.186 5,0.065 7 min-1。结论:秦皮甲素在小肠吸收迅速完全,其吸收呈一级吸收动力学特征且吸收机制为被动转运,适于制成缓释给药系统。

Absorption Kinetics of Aesculin in Rats

Objective: To investigate the absorption characteristics of aesculin in different intestinal segments of rats. Method: The study was performed by intestinal perfusion model in rats to observe the effect of absorption sites and concentrations on absorption kinetics of aesculin. Result: Aesculin had specific site in rat's intestine, absorption rate constants were 0.185 0, 0.186 5, 0.065 7 min^-1 in duodenum, jejunum and ileum respectively. Conclusion: Aesculin was rapidly and completely absorbed in whole segments of intestine. The behaviors conformed to passive-transport mechanism and first-order kinetics. All the above indicated that aesculin could be formulated to a sustained-release drug delivery system.