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| 哮喘患者IL—10水平与IgE含量的关系 | |
| 引用本文： | 王利民 李学义. 哮喘患者IL—10水平与IgE含量的关系[J]. 现代免疫学, 1998, 18(6): 358-360 |
| 作者姓名： | 王利民 李学义 |
| 作者单位： | [1]上海第二医科大学附属仁济医院分子生物学中心实验室 [2]上海市免疫学研究所 |
| 基金项目： | 国家自然科学基金(39500063)，卫生部基金(96-2-285)资助项目 |
| 摘 要： | 本文用ELISA、细胞培养、RT-PCR方法研究哮喘患者的血浆和单个核细胞IL-10的水平及其与IgE的关系。结果显示32例哮喘患者血浆、细胞培养上清IL-10值和外周血单个核细胞IL-10转录水平均比20例正常人明显降低,血浆IL-10降低组不IgE明显高于血浆IL-10正常组。IL-10是一种抗炎因子,过敏性哮喘患者IL-10浓度降低说明其对过敏性炎症的抑制能力减弱,与哮喘的发病有关。 |
| 关 键 词： | 白介素-10 哮喘 IgE |
Variation of IL-10 in Asthmatics and Relation with Plasma IgE |
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| Wang Limin,Lixueyi,Shen Qiyun,et al.. Variation of IL-10 in Asthmatics and Relation with Plasma IgE[J]. Current Immunology, 1998, 18(6): 358-360 | |
| Authors: | Wang Limin Lixueyi Shen Qiyun et al. |
| Abstract: | In order to study the role of IL-10 in asthmatics and relation with IgE, IL-10 was detected in 32 allergic asthmatics using ELISA, cell culture and RT-PCR. Comparing with those of 20 health controls. The result showed, IL-10 in plasma and cell culture supernatants were significantly lower in asthmatic groups than in control groups. As shown by RT-PCR, the expression of IL-10 mRNA in PBMC was lower in asthmatic groups than in control groups, plasma IgE value in lower IL-10 group were significantly higher than in normal IL-10 group. The results demonstrated that IL-10 may play an important role in the pathogenisis of allergic asthma. |
| Keywords: | IL-10 asthma IgE |
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