喹硫平对酒依赖预防复饮作用的meta分析

目的:使用meta分析的方法探索喹硫平对酒依赖患者预防复饮的作用。方法:在Pubmed、Embase、The Cochrane Library、Web of Science、Ovid和中国知网、万方数据库、维普中文科技期刊数据库进行中英文文献的检索,对检索到的文献进行系统文献筛查,将符合入组标准的文献进行meta分析。结果:最终纳入3篇文献,总样本量341人,meta分析结果显示,服用喹硫平的酒依赖患者与安慰剂组的复饮率差异无统计学意义(OR=0.707,95%CI=0.707~2.209,P=0.551>0.05)。结论:临床使用喹硫平作为预防酒依赖患者复饮的治疗措施仍需谨慎,需要更大样本量、更高质量的研究进一步提供支持证据。

The effect of quetiapine for preventing the relapse in patients with alcohol dependence: a meta-analysis

Objective:We used meta-analysis to explore the effect of quetiapine for preventing the relapse in patients with alcohol dependence.Methods:We searched Pubmed,Embase,The Cochrane Library,Web of Science,Ovid,China Knowledge Network,Wanfang database,Weipu China Science and Technology Journal Database to search English and Chinese papers,and then we systematically screened the papers.We conducted meta-analysis of the papers meeting the inclusion criteria.Results:Three articles were included in the study with the total sample size of 341.The meta-analysis showed no significant difference in the relapse rate between the patients with alcohol dependence and the placebo group(OR=0.707,95%CI=0.707~2.209,P=0.551>0.05).Conclusion:It should be cautious to use quetiapine as a treatment for preventing relapse in patients with alcohol dependence in clinic,and further researches are needed to provide larger sample size and higher quality studies.