男性精液因素对体外受精妊娠结局的影响

目的：探讨男性精液指标与体外受精（IVF）妊娠结局的关系，以指导控制性促排卵周期受精方法的选择。方法：收集郑州大学第一附属医院生殖中心2012年1月—2013年6月第一周期长方案控制性促排卵的2 591个IVF周期，匹配妊娠女方与未妊娠女方的年龄、体质量、不孕原因、基础卵泡刺激素（FSH）和黄体生成激素（LH）、注射人绒毛膜促性腺激素（hCG）日子宫内膜厚度及获卵数等因素，共获得457对，分析不同妊娠结局夫妇中男性因素的差异。结果：妊娠组男性精子正常形态率高于未妊娠组（P＜0.05），但2组精子密度、活力、活率和合格率差异均无统计学意义（P＞0.05）。结论：不同妊娠结局IVF周期精子形态有差异，精液常规分析中的正常形态率较其他指标对IVF妊娠结局具有更高的参考价值。

Effect of Semen-associated Factors on IVF Outcome

Objective: To investigate the effect of sperm relative parameters on the outcome of in vitro fertilization （ＩＶＦ），in order to direct the selection of fertilization method. Methods：Total 2 591 IVF cycles in the controlled ovulation from January 2012 to June 2013 were selected. After matching female factors（age，weight，cause of infertility，base FSH and LH，endometrial thickness on hCG day and the number of acquiring ovum）between pregnant women and non-pregnant women, 457 pairs were analyzed. The sperm relative factors were analyzed in those women with different pregnant outcomes. Results：The rate of normal sperm morphology in pregnant cycles was significantly higher than that in non-pregnancy cycles（P＜0.05），but there was no significant difference in sperm density，activity, survival rate and qudlified rate between two groups（P＞0.05）. Conclusions：There were different rates of normal perm morphology in IVF cycles with different outcomes，suggesting that the rate of normal perm morphology could have good forecasting value for IVF outcomes.