| 瘤型麻风动物模型的NK细胞活性的体外测定 |
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| 引用本文： | 王波,王道若,蒋中华.瘤型麻风动物模型的NK细胞活性的体外测定[J].免疫学杂志,1988(4). |
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| 作者姓名： | 王波 王道若 蒋中华 |
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| 作者单位： | 华西医科大学免疫学研究室 成都
(王波，王道若)，华西医科大学免疫学研究室 成都(蒋中华) |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | 本文报道了瘤型麻风小鼠模型中脾脏NK细胞活性的体外测定,以及加入外源性IL-2对这一活性的影响。结果表明,随着感染时间的延长,小鼠脾脏中NK细胞活性逐渐降低。感染1月小鼠的NK细胞活性明显低于正常小鼠,感染3月小鼠的NK细胞活性较感染1月小鼠更低(P值均<0.01)。将含有IL-2的上清液加入NK细胞活性检测系统中,发现外源性IL-2可逆转感染小鼠的NK细胞活性,使其恢复达正常水平。结合IL-2与NK细胞活性在免疫调节中的作用,对瘤型麻风动物模型的特殊表现作了讨论。
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| 关 键 词： | 鼠麻风杆菌 NK细胞 Yac-1细胞 白细胞介素2 |
The Detection of the Activities of Natural Killer Cells in Animal Models with Lepromatous Leprosy in Vitro |
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| Wang Bo
Laboratory for Immunology,Welt China University of Medical Sciences,Chengdu.The Detection of the Activities of Natural Killer Cells in Animal Models with Lepromatous Leprosy in Vitro[J].Immunological Journal,1988(4). |
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| Authors: | Wang Bo
Laboratory for Immunology Welt China University of Medical Sciences Chengdu |
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| Abstract: | The present paper reports the in vitro tests of the activities of natural killer cells from spleen and the effect of the addition of external IL-2 in animal models with lepromatous leprosy. It was found that the activities of natural killer cells from infected mouse spleen were reduced as time of infection went on. The natural killer activity of infected mice one month after infectioi was lower than that of normal mice (p
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| Keywords: | Mycobacterium lepraemurium Natural killer cell Yac- 1 cell Interleukin- 2 |
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