| 纳络酮对正常人和Cushing病患者胰岛素低血糖兴奋后ACTH分泌的影响 |
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| 引用本文： | 郭爱丽,陆召麟,史轶蘩. 纳络酮对正常人和Cushing病患者胰岛素低血糖兴奋后ACTH分泌的影响[J]. 中华内分泌代谢杂志, 1991, 0(2) |
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| 作者姓名： | 郭爱丽 陆召麟 史轶蘩 |
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| 作者单位： | 北京协和医院内分泌科(郭爱丽，陆召麟)，北京协和医院内分泌科(史轶蘩) |
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| 摘 要： | ![]()
以血清N-POMC水平作为ACTH分泌的指标,观察了纳络酮(25mg)对5例正常人和5例Cushing病患者胰岛素低血糖兴奋后ACTH和皮质醇(F)分泌的影响,发现正常人胰岛素低血糖试验血N-POMC和F水平明显升高;加用类阿片肽受体阻滞剂纳络酮不能使胰岛素低血糖试验时血N-POMC和F的上升幅度进一步增加。推测这两种刺激兴奋CRH的途径相似,提示胰岛素低血糖试验可能涉及到类阿片肽机制。对Cushing病患者,无论是单纯胰岛素低血糖还是胰岛素低血糖加纳络酮均不能改变其血N-POMC和F水平,可能此两种刺激均未能引起内源性CRH释放增加。
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| 关 键 词： | 类阿片肽 纳络酮 N-POMC Cushing病 胰岛素低血糖试验 |
EFFECT OF NALOXONE ON THE SECRETION OF ACTH AND CORTISOL STIMULATED BY INSULIN-INDUCED HYPOGLYCEMIA IN NORMAL SUBJECTS AND PATIENTS WITH CUSHING'S DISEASE |
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| Guo Ai-li,et al.. EFFECT OF NALOXONE ON THE SECRETION OF ACTH AND CORTISOL STIMULATED BY INSULIN-INDUCED HYPOGLYCEMIA IN NORMAL SUBJECTS AND PATIENTS WITH CUSHING'S DISEASE[J]. Chinese Journal of Endocrinology and Metabolism, 1991, 0(2) |
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| Authors: | Guo Ai-li et al. |
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| Affiliation: | Guo Ai-li,et al.Dept. of Endocrinology,PUMC Hospital,Beijing |
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| Abstract: | ![]()
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| Keywords: | Naloxone N-POMC Cushing's disease Hypoglycemia insulin-induced |
| 本文献已被 CNKI 等数据库收录！ |
