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| 非何杰金氏淋巴瘤P16基因纯合性缺失及其临床意义 | |
| 引用本文： | 吉兆宁,刘国卿,许多荣,洪文德. 非何杰金氏淋巴瘤P16基因纯合性缺失及其临床意义[J]. 中国临床药理学与治疗学, 2002, 7(1): 60-62 |
| 作者姓名： | 吉兆宁 刘国卿 许多荣 洪文德 |
| 作者单位： | 1. 中国药科大学药理教研室,南京,210009 2. 中山医科大学附属第一医院血液科,广州,510080 |
| 摘 要： | 目的：探讨P16基因纯合性缺失与非何杰金氏淋巴瘤（NHL）的关系及其临床意义。方法：采用半定量多重PCR检测了51例非休杰金氏淋巴瘤病人P16基因纯合性缺失情况。结果：发现9例病人出现P16基因纯合性缺失，缺失率为17．6％，且低度恶性组与高度恶性组有显性差异（P＜0．05）。结论：P16基因纯合性缺失主要发生于恶性程度较高的HNL中，可作为判断NHL恶性程度高低和决定NHL治疗策略的一个参考指标。 |
| 关 键 词： | P16基因 PCR 非何杰金氏淋巴瘤 基因纯合性缺失 |
| 文章编号： | 1009-2501(2002)01-0060-03 |
| 修稿时间： | 2001-02-05 |
Detection of homozygous P16 gene deletion in Non-Hodgkin''''s Lymphoma by semiquantitative multiplex polymerase reaction and it''''s clinical significance |
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| JI Zhao Ning,LIU Guo Qing,XU Dou Rong ,HONG Wen De. Detection of homozygous P16 gene deletion in Non-Hodgkin''''s Lymphoma by semiquantitative multiplex polymerase reaction and it''''s clinical significance[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2002, 7(1): 60-62 | |
| Authors: | JI Zhao Ning LIU Guo Qing XU Dou Rong HONG Wen De |
| Affiliation: | JI Zhao Ning,LIU Guo Qing,XU Dou Rong 1,HONG Wen De 1 |
| Abstract: | AIM: To investigate the possible relationshop between Non Hodgkin's lymphoma and homozygous deletion of P16 gene. METHODS: Fifty one Non Hodgkin's lymphoma specimens were examined for homozygous deletion of P16 gene by multiplex polymerase chain reaction. RESULTS: Of 51 Non Hodgkin's lymphoma specimens, 9 ( 17.65 %) showed homozygous deletion of P16 gene. There was a significant difference between the low malignancy NHL, and the high malignancy NHL (P< 0.05 ) in homozygous deletion of P16 gene. CONCLUSIONS: Deletion of P16 gene might contribute to the progression of Non Hodgkin's lymphoma and may be one of the important parameters in estimating the prognosis of patients with NHL. |
| Keywords: | Non Hodgkin's lymphoma P16 gene Polymerse chain reaction |
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