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| 二羟基乙二肟致畸作用的实验研究 | |
| 引用本文： | 蒋芸,陈国元,王光祖,彭德慧. 二羟基乙二肟致畸作用的实验研究[J]. 华中科技大学学报(医学版), 1990, 0(Z1) |
| 作者姓名： | 蒋芸 陈国元 王光祖 彭德慧 |
| 作者单位： | 同济医科大学职业医学研究所工业毒理研究室(蒋芸，陈国元，王光祖)，同济医科大学职业医学研究所工业毒理研究室(彭德慧) |
| 摘 要： | 本文报道了二羟基乙二肟(DHG)的致畸作用,并初步探讨了致畸作用机理。结果表明,DHG1250mg/kg对母体和胚胎有毒作用,可引起孕鼠体重减轻、流产、胚胎死亡及活胎生长发育迟缓。畸胎率417mg/kg组为13.64％,1250mg/kg组为43.75％,引起下颌短缺、腭裂等,其致畸指数为12,属弱致畸物。 |
| 关 键 词： | 二羟基乙二肟 致畸胎物 胚胎 细胞分裂抑制 |
An Experimental Study of Teratogenicity of Dihydroxyglyxime |
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| Jiang Yun,Chen Guoyuan,Wang Guangzu,Peng Dehui. An Experimental Study of Teratogenicity of Dihydroxyglyxime[J]. Journal of Huazhong University of Science and Technology(Health Sciences), 1990, 0(Z1) | |
| Authors: | Jiang Yun Chen Guoyuan Wang Guangzu Peng Dehui |
| Affiliation: | Jiang Yun,Chen Guoyuan,Wang Guangzu,Peng DehuiDepartment of Industrial Toxicology,Institute of Occupational Medicine,Tongji Medical University,Wuhan |
| Abstract: | The teratogenicity of dihyroxyglyxime (DHG) was reported and it's mechanism was analyzed tentatively.At the dose of 417 mg/kg,significant toxic effects and malformation to dams and fetus were,observed,including decrease in body weight gain of pregnant rats,abortion,premature death,fetal aplasia,with rate of teratogeny 13.64 %-in 417 mg/kg exposure group and rate of teratogeny 43.75 % in.1 25'0 mg/kg group,including palatine cleft,abnormal mondibular and other malformations.The teratogenicity index was 12,indicating that DHG is a weak teratogen.The above findings suggest that teratogenic mechanism may be related to cell division inhibition. |
| Keywords: | dihydroxyglyxime teratagens embryo cell division inhibition |
| 本文献已被 CNKI 等数据库收录！ | |