A new cytotoxic benzophenanthridine isoquinoline alkaloid from the fruits of Macleaya cordata |
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| Authors: | Hui-Liang Zou Hong-Yu Li Bai-Lian Liu |
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| Affiliation: | 1. Institute of Traditional Chinese Medicine &2. Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy Jinan University, Guangzhou 510632, China |
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| Abstract: | ![]()
A new cytotoxic benzophenanthridine isoquinoline alkaloid, named cordatine (1), together with one known alkaloid 8-methoxydihydrochelerythrine (2), was isolated from the fruits of Macleaya cordata. The structure of the new compound was elucidated by spectroscopic methods including 1D and 2D NMR, HR-ESI-MS. Both compounds indicated significant cytotoxicity against MCF-7 and SF-268 cell lines. |
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| Keywords: | Macleaya cordata benzophenanthridine alkaloid cordatine |
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