A novel analgesic pyrazine derivative from the leaves of Croton tiglium L. |
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| Authors: | Xin-An Wu Neng-Jiang Yu |
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| Affiliation: | Laboratory of Phytochemistry , Beijing Institute of Pharmacology and Toxicology , Beijing, 100850, China |
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| Abstract: | A novel analgesic pyrazine derivative, named crotonine, was isolated from the leaves of Croton tiglium L. The structure was elucidated as 2-(furan-2-yl)-5-(2,3,4-trihydroxy-butyl)-1,4-diazine by spectroscopic analysis. Crotonine inhibited remarkably the acetic acid-induced writhing in mice. |
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| Keywords: | Croton tiglium L Euphoriaceae 2-(Furan-2-yl)-5-(2,3,4-trihydroxy-butyl)-1,4-diazine Crotonine analgesic effects |
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