Two new coumarin glycosides from Herpetospermum caudigerum |
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| Authors: | Bing Xu Shuang Liu Xu-Dong Fan Li-Qing Deng Wen-Hui Ma |
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| Affiliation: | 1. Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China;2. Shanghai Micronmr Information Technology Co., Ltd., Shanghai 200437, China |
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| Abstract: | ![]()
Phytochemical investigation on the seeds of Herpetospermum caudigerum afforded two new coumarin glycosides A and B (1 and 2), together with a known compound herpetolide A (3). Their structures were determined by spectroscopic methods, including 2D NMR techniques. Compound 3 exhibited cytotoxicity against HepG2 cells with IC50 value of 6.47 μg/ml. Compound 2 showed anti-hepatitis B virus activity with HBsAg secretion by 33.1% at 200 μg/ml. |
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| Keywords: | Herpetospermum caudigerum coumarin glycoside herpetosperin A herpetosperin B |
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