Ceramides and cerebrosides from the marine bryozoan Bugula neritina inhabiting South China Sea |
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| Authors: | Xiang-Rong Tian Yu-Shan Li Hou-Wen Lin Ning Ma Wei Zhang |
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| Institution: | 1. Department of Pharmacy , Xijing Hospital, Fourth Military Medical University , Xi'an, 710032, China;2. School of Traditional Chinese Medicines, Shenyang Pharmaceutical University , Shenyang, 110016, China;3. School of Traditional Chinese Medicines, Shenyang Pharmaceutical University , Shenyang, 110016, China;4. Department of Pharmacy , Changzheng Hospital, Second Military Medical University , Shanghai, 200003, China;5. Department of Pharmacy , Xijing Hospital, Fourth Military Medical University , Xi'an, 710032, China |
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| Abstract: | From the marine bryozoan Bugula neritina inhabiting South China Sea, a new ceramide named (2S,3R,4E)-2-(14′-methyl-pentadecanoylamino)-4-octadecene-l,3-diol (1) and a new cerebroside named 1-O-(β-d-glucopyranosyl)-(2S,3R,4E)-2-(heptadecanoylamino)-4-octadecene-l,3-diol (6), together with one known ceramide (2) and three known cerebrosides (3, 4, and 5), were isolated. Their structures were deduced by extensive spectral analysis and chemical evidences. Compound 1 is branched with a methyl –CH(CH3)2] in the fatty acid moiety, which is a rare structural feature among ceramides. Compound 6 is a new cerebroside with 17 carbons in the fatty acid moiety, while 5 is a new natural product which was isolated from a natural origin for the first time. |
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| Keywords: | Bugula neritina cerebroside ceramide (2S 3R 4E)-2-(14′-methyl-pentadecanoylamino)-4-octadecene-l 3-diol d-glucopyranosyl)-(2S" target="_blank">1-O-(β-d-glucopyranosyl)-(2S 3R 4E)-2-(heptadecanoylamino)-4-octadecene-l 3-diol |
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