A bisamide and four diketopiperazines from a marine-derived Streptomyces sp. |
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| Authors: | Bin Li Gang Chen Jiao Bai Yong-Kui Jing |
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| Affiliation: | 1. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang, 110016, China;2. Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education , Shenyang Pharmaceutical University , Shenyang, 110016, China;3. The Mount Sinai School of Medicine , New York, NY, 10029, USA |
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| Abstract: | ![]()
A new bisamide N 1-acetyl-N 7-phenylacetyl cadaverine (1) and a series of diketopiperazines including a new diketopiperazine cyclo(2-hydroxy-Pro-R-Leu) (2), together with a new natural product cyclo(4-hydroxy-S-Pro-S-Trp) (3) and two known leucine-based diketopiperazines cyclo(4-hydroxy-R-Pro-S-Leu) (4) and cyclo (S-Pro-R-Leu) (5), were isolated from ethyl acetate extract of a fermentation broth of a marine-derived Streptomyces sp. Their structures were elucidated by the interpretation of spectroscopic analysis. The antitumor activities of compounds 1–3 against HL-60 cell lines were tested by MTT assay. |
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| Keywords: | marine-derived Streptomyces sp. bisamide diketopiperazine antitumor activity |
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