A study on the chemical constituents of Veratrum nigrum L. processed by rice vinegar |
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| Authors: | Yue Cong Rui Wang Yi-Mei Zeng Chang-Da Liu Xian Li |
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| Affiliation: | 1. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang, China;2. Institute of Traditional Chinese Medica, School of Pharmacy, Henan University , Kaifeng, P.R., China |
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| Abstract: | ![]()
One new steroid alkaloid, 12β-hydroxylveratroylzygadenine (1) and four known compounds, verdine (2), jervine (3), veramarine (4), and veratroylzygadenine (5), have been isolated from the roots and rhizomes of Veratrum nigrum L. processed by rice vinegar. Their structures were established through a combined analysis of physicochemical properties and spectroscopic evidence. The assay results revealed that compounds 1, 4, and 5 exhibited cell toxicity against human HL-60 cells with IC50 values 52.67, 52.90, and 56.51 μmol/l, respectively. |
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| Keywords: | Veratrum nigrum L steroid alkaloid cytotoxicity 12β-hydroxylveratroylzygadenine |
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