A new compound,brefeldin A formylate,from Penicillium sp. strain HLKG-44 |
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| Authors: | Han-Wen Zhang Hong-Ming Cheng Hua Fang Yu-Fen Zhao |
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| Institution: | 1. Key Laboratory for Chemical Biology of Fujian Province College of Chemistry and Chemical Engineering, Department of Chemistry , Xiamen University , Xiamen, China;2. The Third Institute of Oceanography of the State Oceanic Administration , Xiamen, China;3. Key Laboratory for Chemical Biology of Fujian Province College of Chemistry and Chemical Engineering, Department of Chemistry , Xiamen University , Xiamen, China;4. Department of Pharmaceutical Science , Medical College, Xiamen University , Xiamen, China;5. The Key Laboratory for Bioorganic Phosphorus Chemistry and Chemical Biology, National Ministry of Education, Department of Chemistry , Tsinghua University , Beijing, China |
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| Abstract: | A novel compound named as brefeldin A formylate (1), together with two known compounds, brefeldin A (2) and ergosterol (3), was isolated from the Penicillium sp. strain HLKG-44, which was isolated from polluted environment in Fujian Province. Their structures were identified based on the spectral and X-ray crystallographic analyses. The compound 1, brefeldin A formylate, exhibited moderate cytotoxic activity against the human lung cancer cell line A549 with IC50 value of 18.9 μg/ml by the MTT assay protocol. |
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| Keywords: | Penicillium brefeldin A formylate crystal structure |
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