Two pairs of phenylpropanoid enantiomers from the leaves of Eucommia ulmoides |
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| Authors: | Xu-Liu Shi Jian-Kun Yan Wen-Kai Li Paul Owusu Donkor Xiu-Mei Gao |
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| Institution: | 1. School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300110, China;2. Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300110, China;3. Key Laboratory of Pharmacology of Traditional Chinese Medicine Formulae, Ministry of Education, Tianjin 300110, China;4. College of Science and Technology, Agricultural University of Hebei, Cangzhou 061100, China |
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| Abstract: | AbstractTwo pairs of phenylpropanoid enantiomers, (+)-(7S,8S)-alatusol D (1a), (?)-(7R,8R)-alatusol D (1b), (?)-(7S,8R)-alatusol D (2a) and (+)-(7R,8S)-alatusol D (2b) were isolated from the leaves of Eucommia ulmoides Oliver. Among them, 1a and 2b were firstly obtained by chiral enantiomeric resolution. Their structures were elucidated based on extensive spectroscopic analysis and the induced CD (ICD) spectrum caused by adding Mo2(AcO)4 in DMSO. All compounds were tested on Hep G2 tumor cell lines. However, none of the compounds showed potential cytotoxic activity against Hep G2 in vitro. |
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| Keywords: | Leaves of Eucommia ulmoides phenylpropanoid enantiomers Mo2(AcO)4 absolute configuration Hep G2 |
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