A novel oxybis cresol verticilatin with highly varying degrees of biological activities from the insect pathogenic fungus Paecilomycesverticillatus |
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| Authors: | Pei-Yao Wei Lin Li Chun-Gui Yang Zhi-Hui Zheng Xin-Hua Lu |
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| Affiliation: | 1. Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, College of Life Science, Hebei University, Baoding071002, China;2. Biotechnology Center of Hebei Province, Hebei University, Baoding071002, China;3. New Drug Research and Development Center, North China Pharmaceutical Group Corporation, Shijiazhuang051007, China |
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| Abstract: | ![]()
A novel oxybis cresol compound named verticilatin (1), together with two known compounds, 5-methylresorcinol (2) and 2,4-dihydroxy-3,6-dimethylbenzaldehyde (3), was isolated from cultures of the insect pathogenic fungi Paecilomyces verticillatus. The structures of compounds were determined by extensive spectroscopic analysis of HR-ESI-MS and 1D and 2D NMR including HSQC, HMBC, COSY, and ROESY. Fortunately, compound 1 exhibited significant inhibitory activities against CDC25B, cathepsin B, MEG2, and SHP2 enzyme, with IC50 values of 11.5, 3.5, 7.8, and 15 μg/ml, respectively. |
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| Keywords: | Paecilomyces verticillatus insect pathogenic fungi verticilatin biological activity |
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