A new hTopo I isomerase inhibitor produced by a mangrove endophytic fungus no. 2240 |
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| Authors: | Ni Tan Xiao-Ling Cai San-Yong Wang Jia-Hui Pan Yi-Wen Tao Zhi-Gang She |
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| Affiliation: | 1. School of Chemistry and Chemical Engineering, Zhongshan University , Guangzhou, China;2. Xiangnan University, Department of Chemistry and Biology , Chenzhou, Hunan, China;3. School of Chemistry and Chemical Engineering, Zhongshan University , Guangzhou, China |
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| Abstract: | ![]()
A new hTopo I isomerase inhibitor, (+)-3,3′,7,7′,8,8′-hexahydroxy-5,5′-dimethylbianthraquinone (2240A), was isolated from the mangrove endophytic fungus no. 2240 collected from an estuarine mangrove at the South China Sea coast. Its structure was elucidated by spectral analyses including two-dimensional NMR, HR-EI-MS, IR, and UV. The hTopo I isomerase inhibition experiment showed that 2240A (1) possessed strong inhibiting activity. When its inhibition concentration was 4.65 μmol/l, its percent inhibition rate was 59.1%, while the lowest inhibition concentration of the positive control camptothecin was 1.00 × 103 μmol/l. |
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| Keywords: | mangrove endophytic fungus (+)-3,3′,7,7′,8,8′-hexahydroxy-5,5′-dimethylbianthraquinone 2240A hTopo I isomerase inhibitor |
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