A new staurosporine analog from Actinomycetes Streptomyces sp. (172614) |
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| Authors: | Xiao-Bin Li Jin-Shan Tang Hao Gao Rong Ding Jia Li Kui Hong |
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| Affiliation: | 1. College of Pharmacy, Institute of Traditional Chinese Medicine and Natural Products, Jinan University , Guangzhou, 510632, China;2. College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang, 110016, China;3. Shanghai Institute of Materia Medica, National Center for Drug Screening, Chinese Academy of Sciences , Shanghai, 201203, China;4. Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences , Haikou, 571101, China |
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| Abstract: | ![]()
A new staurosporine analog, 10′-{5″-[(methoxycarbonyl)amino]-2″-methyl}-phenylaminocarbonylstaurosporine (1), together with staurosporine (2), was obtained from the culture broth of Actinomycetes Streptomyces sp. (172614). Their structures were elucidated by comprehensive spectroscopic analysis including UV, MS, NMR, and CD spectra. Pharmacological experiments revealed that 1 and 2 showed significant cytotoxicity against human colon tumor cell HCT-116. |
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| Keywords: | Streptomyces sp. staurosporine analog cytotoxicity HCT 116 |
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