Transcranial direct current stimulation of the frontal-parietal-temporal area attenuates cue-induced craving for heroin |
| |
| Affiliation: | 1. School of Psychology, Nanjing Normal University, Nanjing, China;2. Department of Psychology, Swansea University, UK;3. Rehabilitation Medicine Center, First Affiliated Hospital of Nanjing Medical University, Nanjing, China;4. Da Lian Shan Institute of Addiction Rehabilitation, Nanjing, China;5. Shanghai University of Traditional Chinese Medicine, Shanghai, China;6. State Key Laboratory of Brain and Cognitive Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China;1. School of Psychology, Nanjing Normal University, Nanjing;2. Rehabilitation Medicine Center, First Affiliated Hospital of Nanjing Medical University, Nanjing;3. Da Lian Shan Institute of Addiction Rehabilitation, Nanjing;4. Chongqing Medical University, Chongqing;5. School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China;1. Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, United States;2. Department of Neurosciences, Medical University of South Carolina, United States;3. Center for Biomedical Imaging, Medical University of South Carolina, United States;4. Ralph H Johnson Veterans Affairs Medical Center, United States;5. Department of Biology, Vanderbilt University, United States;1. Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA;2. Dept of Biostatistics, Epidemiology & Informatics, University of Pennsylvania, Philadelphia, PA, USA;3. Laboratory for Cognition and Neural Stimulation, University of Pennsylvania, Philadelphia, PA, USA;1. Beer Yaakov Mental Health Center, Tel Aviv University, Israel;2. Department of Life Science, Ben-Gurion University, Beer-Sheva, Israel;1. Laboratory of Canada Research Chair in Cognitive Neuroscience, Centre Interdisciplinaire de Recherche en Réadaptation et Intégration Sociale, Centre de Recherche l’Institut Universitaire en Santé Mentale de Québec, Medical School, Laval University, Québec, QC, Canada;2. Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA;3. Center for Neuroscience and Cognitive Systems@UniTn, Italian Institute of Technology, Rovereto, Italy;4. Laboratory of Neuromodulation, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, USA;5. Núcleo de Neurociências, Centro de Ciências Biológicas e da Saúde, Universidade Presbiteriana Mackenzie, São Paulo, SP, Brazil;6. Boston University School of Medicine, Boston Medical Center, Boston, MA, USA;7. Institut Guttmann de Neurorehabilitació, Universitat Autónoma, Barcelona, Spain |
| |
| Abstract: | BackgroundTranscranial direct current stimulation (tDCS) is an effective approach to modulate brain region functions. We assessed if a single tDCS session over the bilateral frontal-parietal-temporal (FPT) areas would reduce cue induced craving in heroin addicts.MethodsTwenty non-treated, long-term heroin-addicted subjects were randomly assigned to receive either real tDCS (1.5 mA, cathodal over bilateral FPT for 20 min) or control tDCS stimulation (turning off the stimulation after 30 s). The participants received heroin cue exposure (containing both injection and inhalation procedures) before and after stimulation and rated their craving after each block of cue presentation.ResultsStimulation of the bilateral FPT with real tDCS for 20 min reduced craving scores significantly (68 ± 8.4 pre-stimulation vs. 43 ± 7.6 post-stimulation, p = 0.003), while the control stimulation group showed no significant changes. No side effects of tDCS were reported.ConclusionsOne session of tDCS over bilateral FPT area significantly reduced subjective craving score induced by heroin cues in heroin addicted subjects. |
| |
| Keywords: | Transcranial direct current stimulation Heroin Craving Frontal-parietal-temporal area |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
