Utility of the Montreal Cognitive Assessment (MoCA) and its subset in HIV-associated neurocognitive disorder (HAND) screening |
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| Affiliation: | 1. Department of Psychiatry, Seonam University College of Medicine, Myongji Hospital, Goyang, South Korea;2. Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, South Korea;3. Department of Internal Medicine and AIDS Research Institute, Yonsei University College of Medicine, Seoul, South Korea;4. Department of Psychiatry, Yonsei University College of Medicine, Seoul, South Korea;5. Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, South Korea;6. Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea;1. Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami and Center of Aging, Miami, FL;2. Wien Center for Alzheimer''s Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL;3. Wien Center for Alzheimer''s Disease and Memory Disorders, Mount Sinai Medical Center, Gainesville, FL;4. Department of Clinical and Health Psychology, University of Florida, Gainesville, FL;5. Department of Neurology, University of Florida, Gainesville, FL;6. Department of Neurology, Florida International University, Miami, FL;7. Avid Radiopharmaceuticals, Philadelphia, PA;1. National Hospital for Neurology and Neurosurgery, Dept. of Neuropsychology, London, United Kingdom;2. UCL Queen Square Institute of Neurology, Stroke Research Centre, London, United Kingdom;3. Comprehensive Stroke Service, University College London Hospital, London, United Kingdom;1. Department of Psychiatry, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia;2. Department of Family Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia;3. Health Psychology Programme, School of Health Care Management, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia;4. Department of Community Health, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia |
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| Abstract: | ![]()
ObjectivesThe Montreal Cognitive Assessment (MoCA) is a useful screening tool for mild cognitive impairment. We aimed to know whether the full MoCA and subsets of the full test are effective for detecting HIV-associated neurocognitive disorder (HAND).MethodsWe examined the socio-demographic, clinical, functional, and neuropsychological levels of 194 HIV-infected patients. We compared total scores and scores from each cognitive domain of MoCA between patients with and without HAND. We also examined the utility of subsets of the full test using a few selective domains. The diagnostic accuracies of MoCA and subset composition were evaluated.ResultsThe total scores of MoCA (P < 0.001) and scores from Trail Making Test-B (P = 0.020), attention domain (P = 0.005), and immediate (P = 0.003) and delayed recall (P = 0.002) differed between patients with and without HAND. A subset composed of Trail Making Test-B, rescored serial subtraction, and immediate/delayed recall showed a 69.2% accuracy.ConclusionsOur results suggest that the MoCA and its subsets alone are not sufficient in screening for HAND. Further studies will be needed to develop a simpler and easier screening tool for HAND based on this study. |
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