| 镉对大鼠肝细胞原癌基因c-myc表达的影响 |
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| 引用本文： | 余日安,陈学敏. 镉对大鼠肝细胞原癌基因c-myc表达的影响[J]. 中国公共卫生, 2000, 16(11): 995-996 |
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| 作者姓名： | 余日安 陈学敏 |
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| 作者单位： | 同济医科大学环境卫生学教研室武汉430030 |
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| 基金项目： | 系国家自然科学基金资助项目 |
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| 摘 要： | 应用Ｎｏｒｔｈｅｒｎ斑点杂交方法研究氯化镉对大鼠肝细胞原癌基因ｃ－ｍｙｃ表达的影响。结果表明，５ｕｍｏｌ／ｋｇ、１０ｕｍｏｌ／ｋｇ、２０ｕｍｏｌ／ｋｇ氯化镉腹腔一次注射邱，大鼠肝细胞ｃ－ｍｙｃｍＲＮＡ较对照组明显增多，用免疫组化技术在大鼠肝细胞中检测到ｃ－ｍｙｃ蛋白。结果提示，氯化镉可以引起在体大鼠肝细胞ｃ－ｍｙｃ表达增强。
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| 关 键 词： | 镉 c－myc 肝细胞 致癌物 表达 原癌基因 |
| 修稿时间： | 2000-03-17 |
The Effects of Cadmium on Proto - oncogene c - myc Expression in Rat Liver Cells, in Vivo Studies |
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| Yu Rian,et al.. The Effects of Cadmium on Proto - oncogene c - myc Expression in Rat Liver Cells, in Vivo Studies[J]. Chinese Journal of Public Health, 2000, 16(11): 995-996 |
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| Authors: | Yu Rian et al. |
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| Affiliation: | Wuhan 430030 |
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| Abstract: | The research studied the effects of cadmium chloride on proto- oncogene c - myc expression in rat liver cells with Northern DotHybridization. The results showed: at the dose of 5μmol/kg,10μnol/kg, 20μmol/kg, cadmium chloride can induce proto-oncogene c - myc expression obviously and c - myc protein can bedetected in rat liver cells with immunohistochemistry. The re-search infers that at certain dose, cadmium can induce proto -oncogene c - myc expression in rat liver cells. |
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| Keywords: | Cadmium c-myc Oncogene |
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