美罗华联合CHOP方案治疗滤泡型非霍奇金氏淋巴瘤1例

目的]评价美罗华联合CHOP方案治疗滤泡型NHL的临床效果及不良反应.方法]第1天:美罗华375mg/m2,600 mg静点;地塞米松15 mg静推;第2天:环磷酰胺750 mg/m2,1.2 g静推;长春新碱1.4 mg/m2,2mg静推;法玛新60 mg/m2,110 mg静推;第2～5天:强的松100毫克口服.每21天1周期,连用7周期.结果]完全缓解.毒副反应主要是骨髓抑制Ⅲ°、口腔炎Ⅲ°、便秘Ⅲ°、脱发Ⅱ°、恶心呕吐I°,可耐受.结论]美罗华联合CHOP方案治疗滤泡型NHL可获得较好疗效,毒副反应可以耐受,是一个较好的化疗方案.

A case of combined chemotherapy of CHOP with Rituximab in FL

Objective] To evaluate the results of combined Rituximab with CHOP in the chemotherapy of follicular lymphoma.Methods] A patient with follicular lymphoma received Rituximab 375mg/m2 by intravenous infusion on the fifth day,Dexamethasone 15mg by intravenous on the first day,Cytoxan 750 mg/m2 by intravenous on the second day,Vinblastine 1.4mg/m2 by intravenous on the second day.Epirubicin Hydrochloride 60 mg/m2 by intravenous on day2.Prednisone 100 mg by Poon the second day to the fifth day.The treatment was repeated every 21 days,up to 7 cycles.Results] CR.The main toxicities were myelosuppression,oral inflammation,constipation,alopecia,nausea and other side effects.Conclusion] A high response rate can be obtained in follicular lymphoma by CHOP plus Rituximab.It is a promising antitumor agent with tolerable toxicity.