寻常型天疱疮发病机制的进展

寻常型天疱疮是一累及皮肤和黏膜的自身免疫性大疱性皮肤病,在各型天疱疮中最常见.国内外一直在进行其发病机制的研究,目前尚不完全清楚,其中.最有影响的是桥粒芯糖蛋白的补偿学说.随着免疫学、分子生物学的不断发展,提出更多的发病机制,包括抗体介导的细胞凋亡学说、基底细胞塌陷皱缩假说等.这将有利于进一步发现治疗寻常型天疱疮乃至其他自身免疫病的新靶点,指导临床治疗.

Pathogenesis of pemphigus vulgaris

Pemphigus vulgaris is an autoimmune blistering disease involving skin and mucous membranes. It is the most common and severe clinical type of pemphigus with much a high mortality. Although studies have been carried out at home and abroad, little is known about its pathogenesis. Among these hypotheses, the desmoglein compensation theory is the most influential. Meanwhile, following the development of immunology and molecular biology, more possible theories on PV have been proposed, including the antibody-induced apoptosis theory, basal cell shrinkage hypothesis, and so on, which may hasten the search for new treatment targets of PV and other autoimmune diseases, and subsequently favor their treatment.