| 复方首乌藤合剂对小鼠的促智作用研究 |
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| 引用本文： | 张荣,田文君,陈亚惠.复方首乌藤合剂对小鼠的促智作用研究[J].海峡药学,2006,18(6):35-38. |
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| 作者姓名： | 张荣 田文君 陈亚惠 |
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| 作者单位： | 中国人民解放军第175医院,厦门大学附属东南医院,药剂科,漳州,360035;中国人民解放军第175医院,厦门大学附属东南医院,药剂科,漳州,360035;中国人民解放军第175医院,厦门大学附属东南医院,药剂科,漳州,360035 |
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| 摘 要： | 目的研究复方首乌藤合剂对小鼠的促智活性。方法采用跳台法。结果复方首乌藤合剂能增强自然衰老小鼠的学习和记忆能力,并对分别由东莨菪碱、亚硝酸钠和40%乙醇引起的小鼠记忆获得、记忆巩固和记忆再现病理模型有较明显的改善作用。结论复方首乌藤合剂中含有促智活性物质,它可能是本品具有良好临床疗效的物质基础。
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| 关 键 词： | 复方首乌藤合剂 促智 跳台法 |
| 文章编号： | 1006-3765（2006）06-0035-04 |
The Study of Nootropic Effect of Compound Caulis Polygoni Multiflori Mixture in Mice |
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| ZHANG-Rong,TIAN Wen-jun,CHEN Ya-hui.The Study of Nootropic Effect of Compound Caulis Polygoni Multiflori Mixture in Mice[J].Strait Pharmaceutical Journal,2006,18(6):35-38. |
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| Authors: | ZHANG-Rong TIAN Wen-jun CHEN Ya-hui |
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| Institution: | The Pharmacy Department, the 175th Hospital of PLA ,Zhangzhou, in Mice 363000 Cina |
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| Abstract: | OBJECTIVE To study the nootropic effect of compound Caulis Polygoni Multiflori mixture in mice.METHODS Water-maze test and Step-down test were used to evaluate the nootropic effect. RESULTS The compound Caulis Polygoni Multiflori mixture could increase learning and memory ability of old mice and also improve the impairments of memory acquisition,memory consodilidation and memory retrieval induced by scopolamine,NaNO_2 and 40% Ethanol in mice,respectively.CONCLUSION The compound Caulis Polygoni Multiflori mixture contains the substances of increasing intelligence which may be the substantial basis of the drug having significant clinical therapeutic effect. |
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| Keywords: | Compound Caulis Polygoni Multiflori mixture Nootropic effect Step-down test |
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