定量检测降钙素原在感染性疾病诊疗中的研究进展

降钙素原是一项高敏感性和特异性的炎症指标,在感染性疾病的诊断、鉴别诊断和治疗中有着重要价值.目前,临床上应用的多为降钙素原定性检测方法,其在结果判读和检测范围上有一定的限制,而降钙素原定量检测应用酶联荧光分析原理,能及时准确地检测血清降钙素原水平,更加适用于感染性疾病的诊断及治疗效果评估.此文就降钙素原的构成、特性、定量检测方法及其在感染性疾病诊疗中的应用等进行了综述.

Advances in procalcitonin quantitative detection for the diagnosis and therapy of infectious diseases

As the mediator of inflammation, procalcitonin is a new marker of high sensitivity and specificity, and also has significant value in the diagnosis, differential diagnosis and therapy of infectious diseases. At present, the detection of procalcitonin is mainly in the method of semi-quantification, and this method has some limitations in the detection range and result interpretation. However, the quantitative detection of procalcitonin is in the modus of enzyme-linked fluorescent assay exactly and promptly, which is especially used for the diagnosis and therapy of infectious diseases. This review is mainly about procalcitonin structure, metabolism, quantitative detection and clinical application in infected diseases.