胃肠道类癌的诊治和预后分析

目的探讨胃肠道类癌的诊断治疗和预后影响因素。方法对1998年12月至2007年12月间收治的40例胃肠道类癌患者的临床资料进行回顾性分析。结果40例患者男女比例1.86∶1,平均年龄59.3岁。主要临床表现为腹部疼痛、消化道出血和腹泻。病灶中位大小4 cm,肿瘤直径≤2 cm者5年生存率88%,直径>2 cm者5年生存率为32%(P=0.0038)。T1-2、T3和T4期患者的5年生存率具有明显差异(P<0.01),分别为82%、44%和17%。不伴有淋巴结转移者和伴有淋巴结转移者的5年生存率分别为80%和31%(P=0.0017),总5年生存率52%。结论手术是胃肠道类癌的主要治疗手段,预后和肿瘤大小、浸润深度以及淋巴结转移相关。

Treatment and prognositic anlysis of gastrotestinal carcinoid tumors

Objective To explore the diagnosis and management of gastrointestinal careinoid tumors and ana-lyze its prognostic factor.Methods Clinical data of 40 patients with gastrointestinal carcinoid tumors were retrospec-tively analyzed from Dec.1998 to Dec.2007.Results The average age of the patients was 59.3 years old,with male to female ratio of 1.86:1.The major symptoms included upper abdominal pain,gut bleeding and diarrhea.The average diameter of the tumors Was 4cm.The 5-year survival rate of patients with tumor size ≤2 cm was 88%.which was sig-nificantly higher than that(32%)for those with tumor size >2 cm in size(P=0.0038).The 5-year survival rate of the patients with T1-2,T3 and T4 Wag 82%,44% and 17%(P<0.01),respectively.For the patients without lymph node metastasis,their 5-years survival rate Was 80%,and the rate of those with lymph node metastasis was only 31%(P=0.0017).The overall 5-year survival rate of the 40 cases was 52%.Conclusions Radical resection is the pri-mary treatment for gastrointestinal earcinoid tumors.The prognosis of gastrointestinal carcinoid tumors is correlated to the size of tumor,depth of invasion and lymph node metastasis.