| 不同浓度一氧化碳对大鼠脂质过氧化及谷胱甘肽过氧化物酶的影响 |
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| 引用本文： | 龚诚华,刘君卓,王黎华. 不同浓度一氧化碳对大鼠脂质过氧化及谷胱甘肽过氧化物酶的影响[J]. 环境与健康杂志, 1995, 0(3) |
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| 作者姓名： | 龚诚华 刘君卓 王黎华 |
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| 作者单位： | 北京医科大学环境卫生学教研室 |
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| 摘 要： | 不同浓度一氧化碳对大鼠脂质过氧化及各胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）的影响研究结果表明：大鼠在５００ｍｇ／ｍ３ＣＯ染毒下，第２０天血液中的脂质过氧化物及第３０天心脏组织的脂质过氧化物均明显升高，而５０、２５ｍｇ／ｍ３ＣＯ染毒则未见上述变化。但自２５ｍｇ／ｍ３浓度开始，ＧＳＨ－Ｐｘ活性即发生明显变化。提示ＣＯ能诱发自由基导致脂质过氧化；也说明ＧＳＨ－Ｐｘ是ＣＯ对机体影响的早期敏感指标之一。本研究可为室内ＣＯ卫生标准的制订提供部分新的资料。
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| 关 键 词： | 一氧化碳，脂质过氧化，谷胱甘肽过氧化物酶 |
The Effects of CO at Low Concentration on Lipid Peroxidation and Glutathione Peroxidase in Rats |
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| Gong CH,Liu JZ, Wang LH.. The Effects of CO at Low Concentration on Lipid Peroxidation and Glutathione Peroxidase in Rats[J]. Journal of Environment and Health, 1995, 0(3) |
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| Authors: | Gong CH Liu JZ Wang LH. |
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| Abstract: | In this paper,we observed the effects of CO at low concentration on lipid peroxidation and glutathione peroxidase (GSH-Px).The results showed that the lipid peroxide (MDA)in plasma increased significantly when rats exposed to 500mg/m3 CO for 20 days and so was in its heart tissue for 30 days,the changes mentioned above for 50,25mg/m3 CO were not observed,but 25 mg/m3 CO caused the changes of GSH-Px. These results indicated that CO can induce free radical,then form lipid peroxide;and suggested that GSH-Px was a early sensitive index about the effects of CO. The results could be used ad the new evidence in setting up indoor air CO criterion. |
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| Keywords: | Carbon Monoxide Lipid peroxidation Glutathione Peroxidase Free radical |
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