| 矮紫堇生物碱成分 |
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| 引用本文： | 高燕萍,吴强,梁健,王洪玲,钟囯跃.矮紫堇生物碱成分[J].中国实验方剂学杂志,2016,22(17):67-70. |
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| 作者姓名： | 高燕萍 吴强 梁健 王洪玲 钟囯跃 |
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| 作者单位： | 江西中医药大学 中药资源与民族药研究中心, 南昌 330000,江西中医药大学 科技学院, 南昌 330000,江西中医药大学 中药资源与民族药研究中心, 南昌 330000,江西中医药大学 中药资源与民族药研究中心, 南昌 330000,江西中医药大学 中药资源与民族药研究中心, 南昌 330000 |
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| 基金项目： | 江西省卫生和计划生育委员会项目（2014A030）；科研课题-校级项目（JXXT201402023） |
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| 摘 要： | 目的:研究藏药矮紫堇生物碱部位的化学成分。方法:通过反复硅胶柱色谱,羟丙基葡聚糖凝胶(Sephadex LH-20),制备薄层色谱和半制备高效液相色谱等技术进行分离纯化,通过理化性质,运用NMR,MS等波谱方法以及结合文献数据对分离得到的化合物进行结构鉴定。结果:从矮紫堇乙醇提取物的总生物碱部位中分离鉴定了11个化合物,分别为9-methyldecumbenine C(1),原阿片碱(2),别隐品碱(3),四氢黄连碱(4),四氢小檗碱(5),四氢巴马亭(6),tetrahydrocolumbamine(7),奥柯紫堇明碱(8),fumariline(9),二氢血根碱(10),小檗碱(11)。结论:化合物3和5~11为首次从该植物中分离得到。
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| 关 键 词： | 矮紫堇 生物碱 化学成分 结构鉴定 |
| 收稿时间： | 2016/3/13 0:00:00 |
Alkaloids from Corydalis hendersonii |
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| GAO Yan-ping,WU Qiang,LIANG Jian,WANG Hong-ling and ZHONG Guo-yue.Alkaloids from Corydalis hendersonii[J].China Journal of Experimental Traditional Medical Formulae,2016,22(17):67-70. |
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| Authors: | GAO Yan-ping WU Qiang LIANG Jian WANG Hong-ling and ZHONG Guo-yue |
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| Institution: | Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Jiangxi University of Traditional Chinese Medicine(TCM), Nanchang 330000, China,Science and Technology College, Jiangxi University of TCM, Nanchang 330000, China,Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Jiangxi University of Traditional Chinese Medicine(TCM), Nanchang 330000, China,Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Jiangxi University of Traditional Chinese Medicine(TCM), Nanchang 330000, China and Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Jiangxi University of Traditional Chinese Medicine(TCM), Nanchang 330000, China |
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| Abstract: | Objective: To study the chemical constituents of Tibet medicine Corydalis hendersonii. Method: The chemical constituents were isolated through combined techniques, silica gel, Sephadex LH-20, preparative TLC and semi-preparative HPLC, and their structures were determined on the basis of physicochemical properties, MS and NMR spectroscopic analysis and literature data. Result: Eleven alkaloids were isolated from the total alkaloids part of ethanol extract from C. hendersonii. Their structures were identified as 9-methyldecumbenine C(1), protopine(2), allocrytopine(3), stylopine(4), tetrahydroberberine(5), tetrhydropalmatine(6), tetrahydrocolumbamine(7), ochotensimine(8), fumariline(9), dihydrosanguinarine(10), and berberine(11). Conclusion: Compounds 3 and 5-11 were obtained from this species for the first time. |
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| Keywords: | Corydalis hendersonii alkaloids chemical constituent structural identification |
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