| 基于谱动学研究金(山)银花的生物等效性 |
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| 引用本文： | 贺红,杨姣,胡超,周逸群,唐宇,周晋,贺福元. 基于谱动学研究金(山)银花的生物等效性[J]. 中国实验方剂学杂志, 2016, 22(16): 1-5 |
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| 作者姓名： | 贺红 杨姣 胡超 周逸群 唐宇 周晋 贺福元 |
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| 作者单位： | 湖南中医药大学 药学院, 中药药性与药效国家中医药管理局重点实验室, 现代中药制剂制备技术与 评价实验室, 中医药超分子机理与数理特征化实验室, 长沙 410208,湖南中医药大学 药学院, 中药药性与药效国家中医药管理局重点实验室, 现代中药制剂制备技术与 评价实验室, 中医药超分子机理与数理特征化实验室, 长沙 410208,湖南中医药大学 药学院, 中药药性与药效国家中医药管理局重点实验室, 现代中药制剂制备技术与 评价实验室, 中医药超分子机理与数理特征化实验室, 长沙 410208,湖南中医药大学 药学院, 中药药性与药效国家中医药管理局重点实验室, 现代中药制剂制备技术与 评价实验室, 中医药超分子机理与数理特征化实验室, 长沙 410208,湖南中医药大学 药学院, 中药药性与药效国家中医药管理局重点实验室, 现代中药制剂制备技术与 评价实验室, 中医药超分子机理与数理特征化实验室, 长沙 410208,湖南中医药大学 药学院, 中药药性与药效国家中医药管理局重点实验室, 现代中药制剂制备技术与 评价实验室, 中医药超分子机理与数理特征化实验室, 长沙 410208,湖南中医药大学 药学院, 中药药性与药效国家中医药管理局重点实验室, 现代中药制剂制备技术与 评价实验室, 中医药超分子机理与数理特征化实验室, 长沙 410208 |
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| 基金项目： | 国家自然科学基金项目（81270055，81573691）；湖南省自然科学基金项目（2015JJ2111）；湖南中医药大学研究生创新课题（2015CX18） |
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| 摘 要： | 目的:运用中药谱动学研究方法对金银花、山银花的生物等效规律进行探索求证。方法:通过口服给药的方式,对3组SD大鼠分别给予金银花提取液、山银花提取液和水2 m L,分别于给药后0.25,0.5,1,1.5,2,3,4,6,8,12,24 h后取血,通过HPLC测定血样中药物的代谢指纹图谱,运用谱动学公式计算药物动力学参数与谱动学参数。结果:金银花谱动学总量零阶矩、整体药物代谢一阶矩、整体药物代谢二阶矩、指纹图谱特征峰总量一阶矩和指纹图谱特征峰总量二阶矩参数分别为1 621.014μg·min·L~(-1),12.632 min,34.717 min~2,16.088 min和16.626 min~2;山银花谱动学这些参数分别为1 769.339μg·min·L~(-1),13.308 min,38.929 min~2,16.569 min和17.391 min~2,两组数据经SPSS 17.0软件配对t检验,双侧P=0.352,说明两者的谱动学参数不具有统计学差异。结论:金(山)银花血药浓度随时间的变化规律基本上同步,金银花、山银花在体内代谢效应相同。
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| 关 键 词： | 金银花 山银花 中药谱动学 指纹图谱 生物等效性 |
| 收稿时间： | 2015-10-12 |
Bioequiavailability Research Between Lonicerae Japonicae Flos and Lonicerae Flos Based on Chromatokinetics |
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| HE Hong,YANG Jiao,HU Chao,ZHOU Yi-qun,TANG Yu,ZHOU Jin and HE Fu-yuan. Bioequiavailability Research Between Lonicerae Japonicae Flos and Lonicerae Flos Based on Chromatokinetics[J]. China Journal of Experimental Traditional Medical Formulae, 2016, 22(16): 1-5 |
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| Authors: | HE Hong YANG Jiao HU Chao ZHOU Yi-qun TANG Yu ZHOU Jin HE Fu-yuan |
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| Affiliation: | Laboratory of Supramolecular Mechanism and Mathematic-physics Chracterization of Traditional Chinese Medicine(TCM), Laboratory of Pharmaceutical Preparation Technology and Evaluation of Modern Chinese Materia Medica, Key Laboratory of Chinese Materia Medica Property and Pharmacodaynamic, State Administration of TCM, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China,Laboratory of Supramolecular Mechanism and Mathematic-physics Chracterization of Traditional Chinese Medicine(TCM), Laboratory of Pharmaceutical Preparation Technology and Evaluation of Modern Chinese Materia Medica, Key Laboratory of Chinese Materia Medica Property and Pharmacodaynamic, State Administration of TCM, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China,Laboratory of Supramolecular Mechanism and Mathematic-physics Chracterization of Traditional Chinese Medicine(TCM), Laboratory of Pharmaceutical Preparation Technology and Evaluation of Modern Chinese Materia Medica, Key Laboratory of Chinese Materia Medica Property and Pharmacodaynamic, State Administration of TCM, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China,Laboratory of Supramolecular Mechanism and Mathematic-physics Chracterization of Traditional Chinese Medicine(TCM), Laboratory of Pharmaceutical Preparation Technology and Evaluation of Modern Chinese Materia Medica, Key Laboratory of Chinese Materia Medica Property and Pharmacodaynamic, State Administration of TCM, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China,Laboratory of Supramolecular Mechanism and Mathematic-physics Chracterization of Traditional Chinese Medicine(TCM), Laboratory of Pharmaceutical Preparation Technology and Evaluation of Modern Chinese Materia Medica, Key Laboratory of Chinese Materia Medica Property and Pharmacodaynamic, State Administration of TCM, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China,Laboratory of Supramolecular Mechanism and Mathematic-physics Chracterization of Traditional Chinese Medicine(TCM), Laboratory of Pharmaceutical Preparation Technology and Evaluation of Modern Chinese Materia Medica, Key Laboratory of Chinese Materia Medica Property and Pharmacodaynamic, State Administration of TCM, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China and Laboratory of Supramolecular Mechanism and Mathematic-physics Chracterization of Traditional Chinese Medicine(TCM), Laboratory of Pharmaceutical Preparation Technology and Evaluation of Modern Chinese Materia Medica, Key Laboratory of Chinese Materia Medica Property and Pharmacodaynamic, State Administration of TCM, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China |
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| Abstract: | |
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| Keywords: | Lonicerae Japonicae Flos Lonicerae Flos chromatokinetics of Chinese materia medica fingerprint bioequiavailability |
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