单倍体异基因造血干细胞移植治疗急性白血病疗效观察

目的观察单倍体异基因造血干细胞移植（Haplo—SCT）治疗急性白血病的疗效。方法对我科2006年6月至2007年12月5例急性白血病患者进行单倍体异基因造血干细胞移植，预处理方案：改良马利兰与环磷酰胺（BU／CY）方案。移植物抗宿主病（GVHD）预防：环孢素A、短程甲氨喋呤、霉酚酸酯和抗-CD25抗体。结果5例患者全部获得造血重建。1例因合并Ⅲ度肠道急性移植物抗宿主病死亡，其余4例随访20～30月，目前均无病存活。结论单倍体异基因造血干细胞移植造血重建稳定，严重并发症少，可作为造血干细胞来源。

Study on HLA-haploidentical hematopoietic stem cell transplantation in treatment of acute leukemia

Objective To analyze the engraftment time and result of HLA - haploidentical hematopoietic stem cell transplantation in treat- ment of acute leukemia. Methods Five cases of acute leukemia had undergone Haplo - SCT in this hospital during June, 2006 to December 2007. The prophylaxis against GVHD was by applying Ciclosporin A （CSA） plus methotrexate, Mycophenolate Mofeil（MMF） and Anti -CD25 monoclonal antibody（ Zenapax）. Results Engraftment was obtained in all patients. One patient died of grade Ⅲ acute intestinal GVHD. The remaining 4 patients were survived with complete remission during the period of follow up for 20 - 30 months. Conclusion These observations suggested that the hematopoietic reconstitution should be done earlier and more durable in haploidentical SCT, and haploidentieal hematopoietic stem cell donor is possible to be served as its source.