| 二氢杨梅素联合阿霉素抗乳腺癌MDA-MB-231细胞增殖的体外研究 |
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| 引用本文： | 周防震,张晓元,郭勇. 二氢杨梅素联合阿霉素抗乳腺癌MDA-MB-231细胞增殖的体外研究[J]. 湖北民族学院学报(医学版 ), 2010, 27(4): 4-7 |
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| 作者姓名： | 周防震 张晓元 郭勇 |
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| 作者单位： | 华南理工大学生物科学与工程学院,广东,广州,510006;湖北民族学院生物科学与技术学院,湖北,恩施,445000;华南理工大学生物科学与工程学院,广东,广州,510006 |
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| 基金项目： | 广东省教育部产学研结合项目 |
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| 摘 要： | 目的体外观察二氢杨梅素（Dihydromyricetin,DMY）联合阿霉素（Adriamycin,ADM）抗人乳腺癌细胞MDA-MB-231增殖的效应。方法采用MTT法观察不同浓度DMY、ADM单独应用对MDA-MB-231细胞生长的抑制作用,并利用中效原理判定两药合用的效应,应用联合作用指数来定量DMY与ADM的联合作用。结果 DMY和ADM对MDA-MB-231细胞有剂量依赖性的增殖抑制作用,作用48h,DMY和ADM的IC50值分别为54.8μg/ml和1.3μg/ml。中效原理分析显示,当抑制效应（Fraction affected,fa）≤0.75时,两药联合应用为协同效应;在相同的抑制效应下可明显降低DMY和ADM单用时的使用剂量。结论 DMY可以增加MDA-MB-231对ADM的敏感性,降低其有效治疗浓度。
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| 关 键 词： | 二氢杨梅素 阿霉素 乳腺癌 中效原理 |
Anti-proliferation effect of combining dihydromyricetin and Adriamycin on MDA-MB-231 cell in vitro |
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| ZHOU Fang-zhen,ZHANG Xiao-yuan,GUO Yong. Anti-proliferation effect of combining dihydromyricetin and Adriamycin on MDA-MB-231 cell in vitro[J]. Journal of Hubei Institute For Nationalities(Medical Edition), 2010, 27(4): 4-7 |
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| Authors: | ZHOU Fang-zhen ZHANG Xiao-yuan GUO Yong |
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| Affiliation: | ZHOU Fang-zhen1,2,ZHANG Xiao-yuan1,GUO Yong1(1.School of Bioscience and Bioengineering,South China University of Technology,Guangzhou 510006,China,2.School of Biological Science and Technology,Hubei University for Nationalities,Enshi 445000,China) |
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| Abstract: | Objective To investigate the antiproliferation effect of dihydromyricetin(DMY) combined with ADMorubicin(ADM) on human breast cancer cell line MDA-MB-231 in vitro.Methods MTT was used to measure inhibitory growth effect of DMY alone,or ADM alone,or DMY combined with ADM on MDA-MB-231 cells and the combination effect was quantitatively determined by using the method of median-effect principle and the combination index.Results Both DMY and ADM inhibited the growth of MDA-MB-231 cells in a dose-dependent manne... |
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| Keywords: | Dihydromyricetin Admorubicin Human breast cancer Median-effect principle |
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