血管紧张素Ⅱ受体、p53和Survivin在乳腺癌中的表达及相关性研究

目的：研究AT1受体、AT2受体、凋亡抑制基因p53、Survivin在乳腺癌中的表达情况,并探讨其相关性及临床意义。方法：采用免疫组化方法（SP法）,对102例乳腺癌患者石蜡包埋切片中的AT1受体、AT2受体、Survivin及p53蛋白进行检测,采用χ^2检验对结果进行分析。结果：乳腺癌组织中AT1受体的阳性表达率为48%（49/102）,AT1受体表达与患者年龄、肿瘤大小、ER、PR无相关性,而与腋淋巴结转移呈正相关;乳腺癌组织中AT2受体的阳性表达率为59.8%（61/102）,AT2受体表达与患者年龄、肿瘤大小、ER、PR无相关性,而与腋淋巴结转移成呈负相关;AT1受体表达与p53、Survivin表达呈正相关,AT2受体表达与p53、Survivin表达呈负相关,AT1受体表达与AT2受体表达呈负相关。结论：血管紧张素Ⅱ受体参与乳腺癌肿瘤细胞凋亡。

A study on the expression of AT1 receptor, AT2 receptor, p53, Survivin and their correlations in breast cancer

Objective：To study the expression of AT1 receptor, AT2 receptor,Survivin,p53 and their correlation in breast cancer. Methods： The expression of AT1 receptor ,AT2 receptor, Survivin, p53 was evaluated in 102 samples paraffin embedded of breast cancer by immunohistochemical technique （SP）. Results： The positive expression rate of AT1 receptor was 48% in breast cancer and the expression of AT1 receptor wasn＇t related to age ,tumor size, ER, PR , there was a positive correlation with lymphnode metastasis. The positive expression rate of AT2 receptor was 59.8% in breast cancer and the expression of AT2 receptor wasn＇ t related to age,tumor size,ER,PR ,there was a negative correlation with lymphnode metastasis, there was a positive correlation between AT1 receptor and p53, Survivin and a negative correlation between AT2 receptor and p53, Survivin , there was a negative correlation between AT1 receptor and AT2 receptor. Conclusion： AT1 receptor,AT2 receptor participate apoptosis of breast cancer .