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| 用核磁共振谱测定庆大霉素注射液中主要组分的研究 | |
| 引用本文： | 王志凌,于永良,陈滇宝. 用核磁共振谱测定庆大霉素注射液中主要组分的研究[J]. 青岛大学医学院学报, 1992, 0(3) |
| 作者姓名： | 王志凌 于永良 陈滇宝 |
| 作者单位： | 青岛医学院附属医院药剂科(王志凌)，青岛化工学院(于永良)，青岛化工学院(陈滇宝) |
| 摘 要： | 用核磁共振谱(~1H-NMR)对庆大霉素(GTM)的主要组分C_1和C_2的百分含量进行了测定,用预饱和抑制水峰谱与GTM原料药的常规谱进行了比较,并对7个厂家的GTM注射液进行了测定分析.结果表明,用抑制水峰法测定GTM注射液中主要组分的含量,简单可行.7个厂家的GTM注射液产品质量亦有差别.提示GTM的组分测定有助于其质量分析和指导临床用药. |
| 关 键 词： | 核磁共振谱法 庆大霉素 组分 化学 分析 |
EVALUATION OF CONSTITUENTS OF GENTAMYCIN INJECTION BY NUCLEAR MAGNETIC RESONANCE SPECTROMETRY |
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| Wang Zhiling,Yu Yongliang,Chen Tianbao. EVALUATION OF CONSTITUENTS OF GENTAMYCIN INJECTION BY NUCLEAR MAGNETIC RESONANCE SPECTROMETRY[J]. Acta Academiae Medicinae Qingdao Universitatis, 1992, 0(3) | |
| Authors: | Wang Zhiling Yu Yongliang Chen Tianbao |
| Affiliation: | Wang Zhiling,Yu Yongliang,Chen Tianbao Department of Pharmacology |
| Abstract: | The main constituents C_1 and C_2 of Gentaminycin (GTM) were evaluated in per centage by nuclear magnetic resonance ( NMR ) spectrometry and comparison of pre - sa - turation water suppression with routine spectrometry of GTM matetrial drug was made to evaluate and analyse the GTM injections produced by 7 different factories. The results showed that the evaluation of the contents of the main constituents of GTM injections by pre-saturation water suppression method is simple and feasible and that GTM injections from 7 factories are different in quality. The study suggests that the evaluation is helpful in ascertaining the quality of the drug and guiding its use clinically. |
| Keywords: | nuclear magnetic resonance spectrometry gentamycin constituents chemical evaluation |
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